Up next for the Jacksonville Jaguars is a home divisional matchup with the Indianapolis Colts.

The Jaguars enter this game at 4-2 and are coming off their bye, as they sit comfortably at the top of the AFC South. The Colts, meanwhile, are 2-5 and have begun trading away key players.

Here is who the experts have winning this game.

Pro Football Talk

Mike Florio likes the Jaguars to win comfortably by a score of 24-9.

"Jacksonville know not to view the Colts as a second straight bye week," he wrote.

CBS Sports

Pete Prisco is also picking the Jaguars to win by multiple scores. Jaguars 30 - Colts 16.

"The Colts are a mess; they are playing consecutive road games, and they haven't won at Jacksonville since 2014, when Andrew Luck was the quarterback," Prisco wrote. "Oh, and they traded their best offensive lineman, Quentin Nelson. The Jaguars are coming off a bye, so they will be rested. This one will get ugly as the Jaguars bounce back from the loss to the Texans in London."

NFL.com

A clean sweep -- all five predictors are picking the Jaguars. Here is why Dan Parr likes Jacksonville in this game:

"Considering the pace of the Colts’ fire sale in advance of the Nov. 10 trade deadline, I’m not sure who will be remaining on Indianapolis’ active roster by the time we get to Sunday. With Quenton Nelson and DeForest Buckner already dealt away for draft picks, what was already going to be an uphill climb against the division-leading Jaguars has grown even steeper in recent days."

ESPN

Three more votes for the Jaguars. ESPN's FPI model also gives Jacksonville a 73.3% chance of winning the game.