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Kazim-Richards took charge in March and helped the club retain its EFL status last season, but a poor start to the League Two campaign ended his first managerial job.
Crawley sit bottom of the table following Tuesday night's 3-2 home defeat to Shrewsbury Town. Kazim-Richards oversaw just one league victory in ten matches this season.
Crawley confirmed Kazim-Richards and assistant Julian Gray had been relieved of their duties with immediate effect, while director of football Erdem Konyar had also departed.
A club statement said: “Crawley Town Football Club can confirm that head coach Colin Kazim-Richards and assistant head coach Julian Gray have been relieved of their duties with immediate effect.”
It added: “The club would like to place on record its sincere thanks to Colin and Julian, who joined during a challenging period and played an important role in securing the club’s EFL status at the end of last season.”
Kazim-Richards had been asked about his future immediately after the defeat to Shrewsbury.
Former Turkey international Colin Kazim-Richards said: “If I felt like I couldn’t and if what we gave the players was not enough then I would definitely think about it. But that is not the case, so the club and Raph [owner Raphael Khalili] it depends on what they feel.”
The former Turkey international retired from playing in 2023 following a career which took him to 18 clubs across eight countries.
Kazim-Richards joined Celtic on a two-and-a-half-year deal in February 2016 and scored twice in 13 appearances before leaving Glasgow at the end of that season.
His career included spells with Sheffield United, Brighton, Blackburn, Derby and QPR, as well as Fenerbahce, Galatasaray, Feyenoord, Toulouse and Olympiacos.