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Reuniting exactly 12 months on from Arsenal's 3-0 win in the 2025-26 league phase, the Gunners and Slavia Prague go head-to-head at the Fortuna Arena in Wednesday's Champions League clash.
Both sides played out engrossing 2-2 draws on matchday three, as Mikel Arteta's side fought back against Bayern Munich while the Czech champions held Fenerbahce.
Here, Sports Mole rounds up the team news for both clubs.
Out: Tomas Chory (suspended), Igoh Ogbu (Achilles), Hamidou Kante (unspecified), Elias Pitak (ankle)
Doubtful: Ivan Schranz (illness), Lukas Provod (unspecified), Ange N'Guessan (unspecified), Jakub Markovic (unspecified), Adonija Ouanda (unspecified)
Sports Mole's predicted XI: Domchak; Vlcek, Holes, Zima; Suleiman, Moses, Sadilek, Kubiak; Ayaosi, Sturm; Nowak
Out: Bukayo Saka (quad), William Saliba (back)
Doubtful: Eberechi Eze (unspecified)
Sports Mole's predicted XI: Raya; White, Konsa, Gabriel, Hincapie; Lewis-Skelly, Rice; Dowman, Odegaard, Eze; Gyokeres