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The Red Devils went 2-0 inside the first 20 minutes against Roma
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Manchester United fans delayed their club's Champions League contest in protest at the ownership.
Several green and gold balloons and tennis balls were thrown from the Stretford End halfway through the first half as supporters voiced their anger at Sir Jim Ratcliffe and the Glazer family.
Matias Soule opened up the scoring after United were carved open through one diagonal ball.
The Argentine had acres of space as he slotted home to put Roma in the lead.
Donyell Malen then converted from 12 yards to make it 2-0 following a handball by Ayden Heaven.
Boos started to ring out around Old Trafford as the home side had no response to the Italian outfit's start.