The 49ers appeared to be set after making a blockbuster trade for DeForest Buckner two weeks before the trade deadline.

But recent events may alter the front office’s course ahead of the Nov. 10 trade deadline. 49ers defensive tackle Gracen Halton sustained a season-ending ankle fracture in Sunday’s win against the Raiders.

A 49ers trade still seemed likely before the deadline as San Francisco played the Raiders short of three key receivers in Mike Evans, Deebo Samuel and Christian Kirk. Evans is dealing with Achilles tendinitis, which could keep him sidelined for weeks, so a trade for a wide receiver seems most likely.

However, the next few days may be even busier if the 49ers look to bolster the defensive line, once again, given the absence of Halton.

Injuries have played an ongoing and unfortunate role for the 49ers this season, but sitting at the top of the NFC West with a 7-1 record certainly puts another perspective on the situation.

But Halton’s season-ending injury could push general manager John Lynch to at least make some calls regarding the defensive line.

San Francisco’s Super Bowl aspirations appeared to be on lock with Buckner’s return to the Bay, but things are looking dim for the organization as injuries continue to plague the team’s success.