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Mikel Arteta says the quadriceps injury Arsenal's Bukayo Saka picked up in the 2-2 Champions League draw against Bayern Munich "does not look good at all".
The 25-year-old winger went down in the 10th minute at Allianz Arena - attempting to play a pass with nobody around him - and had to be replaced by Eberechi Eze, who went on to score the opening goal.
"They are a bit concerned. A player who has to come off with a really sharp pain is never good news but we have to wait and see," Arteta told TNT Sports.
Arsenal's style of play has been criticised this season but, even before Saka's withdrawal, the Gunners played on the front foot and enjoyed more possession than their German opponents.
Losing Saka, who has scored four goals in 11 appearances in all competitions, will be tough to deal with.
But the Gunners have invested heavily in their squad over the past two summer transfer windows and have options.
Madueke can play on both wings, while summer signing Christos Tzolis - although currently out with a hamstring injury - has started the season well.
The Gunners also have 16-year-old Max Dowman as an attacking option, and the youngster has already shown that he can have an impact for the senior side after scoring in the Premier League last season.
Arteta, who was asked what the rest of the forward line will need to do in Saka's absence, said he was pleased with what he saw against Bayern.
"I think Ebs [Eze] had a great game. Not only the ball, but the actions. His overall performance, I think his commitment without the ball as well," he said.
"And when the other ones come in, I think they really contributed to this. First of all, the energy.
"And then to bring different tools that the team needed in that moment to get something out of the game. So, very pleased again."