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Ferrari are not running a rookie in this session, so regular drivers both Lewis Hamilton and Charles are both out on track.
The seven-time world champion is only a point behind George Russell in the fight for second in the standings, and now he's gone above team-mate Leclerc by 0.060 seconds with a time of 1:19.137 on the hard tyre.
The stewards are going to investigate Audi leaving a cooling fan on Freddie Slater's car after the session, and now it looks like the teenager's practice running is over.
With the season drawing to a close and teams needing to run a rookie in the car in four practice sessions during the campaign, this opening hour in Mexico City sees 10 teams changing drivers.
There are two new rookies to look out for on track: Bulgarian Nikola Tsolov, who is second in the Formula 2 championship, and 18-year-old Briton Freddie Slater.
Mercedes
Frederik Vesti replaces George Russell
Red Bull
Ayumu Iwasa replaces Max Verstappen
McLaren
Leonardo Fornaroli replaces Lando Norris
Racing Bulls
Nikola Tsolov replaces Liam Lawson
Alpine
Gabriele Mini replaces Franco Colapinto
Haas
Ryo Hirakawa replaces Esteban Ocon
Audi
Freddie Slater replaces Gabriel Bortoleto
Williams
Luke Browning replaces Alex Albon
Aston Martin
Jak Crawford replaces Lance Stroll
Cadillac
Colton Herta replaces Valtteri Bottas