The Cowboys will play “multiple weeks” without starting tight end Jake Ferguson and backup running back Tyler Goodson, coach Brian Schottenheimer said Monday.

Ferguson sprained the posterior cruciate and the medial collateral ligaments in his left knee in the third quarter Sunday, and Goodson injured his knee in the second quarter but played through it into the second half.

Goodson had a career-high 77 yards on 12 carries against the Colts.

“A lot of these guys, they play on adrenaline, and this is a guy that has been incredible for us really the last two weeks,” Schottenheimer said, via Todd Archer of ESPN. “And these guys, they want to tough it out. They care. They want to win. They want to do whatever it takes. And just doing some more exams and scans and things like that, a few things showed up that we’ll keep an eye [out] for.”

Ferguson is second on the team with four touchdown catches.

The Cowboys have only one slot remaining on the injured reserve designated-to-return list, having already designated seven players.

“We’re working through it,” Schottenheimer said.

Tight end Luke Schoonmaker has missed the past two games with a groin injury but will return this week, Schottenheimer said.

Fullback Hunter Luepke is the only player behind starting running back Javonte Williams on the active roster. Israel Abanikanda and Jashaun Corbin are on the practice squad.

“There’s a lot of different ways to do it,” Schottenheimer said of the running back situation. “I have a lot of confidence in Izzy. We’ll be looking at a lot of different potential moves that we can make, but I’m not going to pretend that losing Goody doesn’t affect us. The guy’s been playing great football.”