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Another notable selection decision sees Ellis Genge dropped to the bench, with Fin Baxter expected to start at loosehead prop.
The decision could be part of Borthwick's plan to introduce Genge later in the match, allowing the experienced prop to provide additional power and impact against tiring opposition.
The remainder of the squad is largely as expected, with George Furbank and Henry Slade reportedly set to start at fullback and outside centre respectively.
Fin Smith is also believed to be fit and available at fly-half, although his potential involvement could raise concerns among supporters.
There are fears that rushing the Northampton Saints playmaker back into action could aggravate his injury and leave him facing a longer spell on the sidelines.
England are expected to officially announce their squad this afternoon, with the reported selections offering an early indication of Borthwick's plans for the Australia clash.
15. George Furbank (Harlequins, 14 caps)
14. Tommy Freeman (Northampton Saints, 30 caps)
13. Henry Slade (Exeter Chiefs, 77 caps)
12. Seb Atkinson (Gloucester Rugby, 7 caps)
11. Immanuel Feyi-Waboso (Exeter Chiefs, 16 caps)
10. Fin Smith (Northampton Saints, 19 caps)
9. Jack van Poortvliet (Leicester Tigers, 27 caps)
1. Fin Baxter (Harlequins, 18 caps)
2. Jamie George (Saracens, 113 caps) – vice-captain
3. Joe Heyes (Leicester Tigers, 25 caps)
4. Maro Itoje (Saracens, 102 caps) – captain
5. Alex Coles (Northampton Saints, 22 caps)
6. Ollie Chessum (Leicester Tigers, 38 caps) – vice-captain
7. Ben Curry (Sale Sharks, 14 caps)
8. Ben Earl (Saracens, 54 caps)
Replacements:
16. Luke Cowan-Dickie (Sale Sharks, 61 caps)
17. Ellis Genge (Bristol Bears, 83 caps) – vice-captain
18. Will Stuart (Bath Rugby, 53 caps)
19. George Martin (Saracens, 24 caps)
20. Greg Fisilau (Exeter Chiefs, uncapped)
21. Henry Pollock (Northampton Saints, 13 caps)
22. Ben Spencer (Bath Rugby, 19 caps)
23. Marcus Smith (Harlequins, 53 caps)