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Arsenal fear Bukayo Saka could miss a minimum of six weeks with the quadriceps injury he sustained in their Champions League tie against Bayern Munich.
The 25-year-old will undergo an MRI scan on Friday afternoon to better assess the problem, which forced him off in Wednesday's 2-2 draw at the Allianz Arena.
Fluid around the affected muscle has made diagnosing the injury difficult, but club medics are estimating, after early examinations, Saka will miss a minimum of six weeks and it could be even longer.
It is a major blow for Mikel Arteta and Arsenal.
The Gunners boss had been speaking about how the player had been adapting his positioning to be more of a regular goalscorer for the club in recent weeks and the winger has scored four goals in 11 appearances so far this season.
But now Saka has gone down with another muscle injury there are questions about whether he still has the robustness that made him a certain starter in the Arsenal team.
The 25-year-old had Achilles, hip and hamstring problems last campaign and underwent surgery on a hamstring injury in the previous season which kept him out for 101 days.
He also had his game time managed at the World Cup in the summer with England and Arteta acknowledged Saka's robustness and availability has "certainly been different in the last year or so".
The Gunners tried to sign a world-class forward to level up their frontline in the summer but were unable to do so, with unsuccessful pursuits of Vinicius Jr and Julian Alvarez.
They did bring in Greece international Christos Tzolis, but he is currently injured too.
That has left them with Noni Madueke, Eberechi Eze and 16-year-old Max Dowman as alternative wing options.
Teenager Dowman has had limited minutes this season but Arteta spoke glowingly of his talent and ability to impact matches.